产品货号：
Z24763
中文名称：
RAN抗体
英文名称：
Anti-RAN Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RAN Antibody |
| 指标别名 | ARA24;Gsp1;GTPase Ran;RAN;Ras like protein TC4;Ras related nuclear protein;TC4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC/IF,FCM |
| 基因名称 | RAN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Ran recombinant protein (Position:A2-L216).Human Ran shares 100% amino acid (aa) sequence identity with both mouse and rat Ran. |
| 实际分子量 | 24KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex.The RAN protein is also involved in control of DNA synthesis and cell cycle progression.Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1).Mutations in RAN disrupt DNA synthesis.Because of its many functions,it is likely that RAN interacts with several other proteins.RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules.RAN could be a key signaling molecule regulating microtubule polymerization during mitosis.RCC1 generates a high local concentration of RAN-GTP around chromatin which,in turn,induces the local nucleation of microtubules.RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor.Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy).RAN coactivation of the AR diminishes with polyglutamine expansion within the AR,and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. |
| Uniprot ID | P62826 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section 1:50～400 Immunocytochemistry in fixed cells 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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